The project deals with the development of sustainable methods of asymmetric catalysis and their application in the synthesis of biologically relevant compounds. Various methods of catalysis (organo-, metal- and enzymatic catalysis) will be used separately or in cooperative manner. Special attention will be turned to the increase of efficiency of reactions by using selective catalysts, cascade or one-pot reactions. As a new method, a halogen bond donor catalyzed asymmetric reactions will be studied. New reactions will be applied on the synthesis of biologically active compounds and their derivatives.
As a result, new asymmetric catalytic sustainable methods for the creating molecular complexity will be developed. Principles of green chemistry will take root in science, in the mode of thinking of PhD students and by PhD graduates in Estonian chemistry enterprises.