Kärt Mätlik

Researches

Publications

Journal / Periodical: Genes & Development
Authors: Mätlik, Kärt; Govek, Eve-Ellen; Hatten, Mary E.
Year: 2025

Projects

Year: 2025 - 2029
This project aims to investigate how epigenetic mechanisms, specifically histone modifications, control gene expression during neuronal development and maturation. We recently discovered that histone bivalency, the simultaneous presence of two histone modifications with opposing functions, controls the timing of gene expression during the maturation of cerebellar neurons. In the proposed studies, we will examine the mechanisms and function of histone bivalency in the adult brain, as well as the species-specific differences in bivalency during mouse and human neuronal development. The research also aims to uncover the molecular mechanisms underlying neurodevelopmental diseases associated with mutations in EZH1, a key enzyme involved in the regulation of bivalent domains. This project will provide fundamental insights into the chromatin mechanisms of brain development and function, with potential implications for understanding and treating neurodevelopmental disorders.

Recognitions

Leon Levy Foundation Postdoctoral Fellowship (2.5 years)
2020
PhD Thesis Award, honorable mention at Estonian National Contest
2019
Sigrid Juselius Foundation Postdoctoral Fellowship (2 years)
2018