Proteins are biopolymers with a myriad of properties and functions: for instance, keratin is the key structural material in our hair and nails, hemoglobin transports oxygen in our blood stream, and digestive enzymes break down food into absorbable components. These diverse functions are directly related to protein structure.<\/p>\n
The goal of the Protein Design Lab is to understand these structure-function relationships in order to develop new proteins with enhanced properties for the benefit of humanity.<\/p>\n
Our main research\u00a0areas cover the development of novel protein-based food additives (e.g., colorants and sweeteners), rational and AI-driven protein design, structural analysis of proteins including X-ray crystallography<\/p>\n
Services we could offer:<\/strong><\/p>\n 1.macromolecular structure analysis using X-ray crystallography, incl colorant, food additive, protein expression and purification, protein modelling and design, structural biology, sweetener, taste receptor, X-ray crystallography<\/p>\n","protected":false},"template":"","tags":[2067,2068,2069,2070,2071,2072,2073,2074],"research_cat":[2057],"class_list":["post-13449","research","type-research","status-publish","hentry","tag-structural-biology","tag-x-ray-crystallography","tag-protein-modelling-and-design","tag-protein-expression-and-purification","tag-food-additive","tag-sweetener","tag-colorant","tag-taste-receptor","research_cat-faculty-of-science"],"acf":{"research_manager":4910,"related_team":[13454,13457,13459,13462,13464]},"yoast_head":"\n
\n*screening and optimization of crystallization conditions using the vapor diffusion method,
\n*X-ray diffraction analysis of crystals, and structure modeling;
\n2. assist with sample preparation, including
\n*heterologous protein expression (in E. coli and K. phaffii systems) and
\n*purification using FPLC (IMAC, IEX, HIC, SEC);
\n3.consultations on computational modeling and docking of macromolecular structures (e.g., AlphaFold, Boltz).
\nEquipment:
\n\u2022pipetting robots ARI Crystal Gryphon and Rigaku Alchemist DT
\n\u2022automated microscope Rigaku Minstrel DT & Gallery
\n\u2022stereomicroscope Nikon SMZ745
\n\u2022X-ray diffractometer Rigaku XtaLAB Synergy-S (Cu-anode source, HyPix-Arc 100 detector)
\nPricing depends on the form of collaboration and is agreed upon individually.<\/p>\n