The main research object of the group is asymmetric organic synthesis.<\/p>\n
The research includes a total synthesis of bioactive compounds and investigations of cascade, including cascade reactions. Studies of asymmetric organocatalytic reactions are of importance. Aminocatalysis based on covalent bound, hydrogen-bond and halogen-bond catalysis based on noncovalent interactions, enzymatic and co-operative catalysis are the main topics. Cascade reactions providing several new chemical bonds in one step are also studied. It increases atom-efficiency, decreases the number of steps needed and makes the whole process environmentally more benign. Practical value to studies is added by the synthesis of human milk oligosaccharides (HMO-s). The synthesis is supported by spectroscopic and crystallographic experiments, chromatography and quantum chemical calculations.The characteristic feature of the research is the application of the principles of sustainable and green chemistry in asymmetric synthesis.<\/p>\n
The most important research result is a new method of the synthesis of a specific HMO (6\u2019-galactosyllactose). This new method is based on the application of the immobilised enzyme (CAL-B). It decreases considerably the number of steps needed for obtaining of the glycosylation donors and acceptors.<\/p>\n
\u200b<\/p>\n
asymmetric synthesis, cascade reactions, catalysis\u200b, halogen-bond catalysis, organocatalysis, synthesis, synthesis of oligosaccharides<\/p>\n","protected":false},"template":"","tags":[1579,1598,1599,1609,1705,1708],"research_cat":[2057],"class_list":["post-5459","research","type-research","status-publish","hentry","tag-halogen-bond-catalysis","tag-cascade-reactions","tag-catalysis","tag-asymmetric-synthesis","tag-synthesis-of-oligosaccharides","tag-organocatalysis","research_cat-faculty-of-science"],"acf":{"research_manager":5033,"related_team":[4661,4427,4721,4554,4451,4660,4711]},"yoast_head":"\n