The group focuses on the biology of leukocyte activation and its regulation. The control of leukocyte activation is of paramount importance for health, both at
\nthe steady state and during the immune response.<\/p>\n
We have selected two families of regulators of which the immune regulatory functions remain poorly understood, the RGS (Regulator of G protein Signalling; main target RGS16) and the purinergic receptors (P2X main targets p2x4 and p2x7). We studied control mechanisms of leukocyte activation mediated by these genes in the context of two pathologies: multiple sclerosis and melanoma. We also followed comparative approaches to understand the importance of these genes in the context of the evolution of the immune system.<\/p>\n
covid-19, eosinophils, immune regulation, leukocyte activation, melanoma, Multiple Sclerosis, P2X4, P2X7, RGS16, SarsCov2<\/p>\n","protected":false},"template":"","tags":[1489,1492,1505,1511,1550,1564,1583,1637,1689,1808],"research_cat":[2057],"class_list":["post-5461","research","type-research","status-publish","hentry","tag-p2x4-en","tag-rgs16-en","tag-immune-regulation","tag-p2x7-en","tag-covid-19-en","tag-eosinophils","tag-multiple-sclerosis","tag-leukocyte-activation","tag-melanoma","tag-sarscov2","research_cat-faculty-of-science"],"acf":{"research_manager":4970,"related_team":[4270,4377,4955]},"yoast_head":"\n