{"id":5469,"date":"2024-11-13T07:32:56","date_gmt":"2024-11-13T05:32:56","guid":{"rendered":"https:\/\/healthandfood.taltech.ee\/?post_type=research&#038;p=5469"},"modified":"2025-04-29T18:05:54","modified_gmt":"2025-04-29T15:05:54","slug":"biomedicine","status":"publish","type":"research","link":"https:\/\/healthandfood.taltech.ee\/en\/researches\/biomedicine\/","title":{"rendered":"Biomedicine"},"content":{"rendered":"<p>Biomedicine lab investigates human pathogen Helicobacter pylori (HP) and its role in the development of liver diseases. HP is a Gram-negative bacterium living in the hostile environment of the human stomach. About 70% of the adult population in Estonia is infected with HP. The bacterium causes gastritis and peptic ulcers, and, in some cases, gastric cancer. HP can also affect other organs including the liver. However, the mechanisms by which HP causes liver damage and promotes carcinogenesis remain largely unknown. Ongoing research is expected to increase our understanding of the mechanisms behind bacteria-induced carcinogenesis.<\/p>\n<p>Main research topics include:<\/p>\n<ul>\n<li>Role of Helicobacter pylori-induced invadosomes in liver damages. We have previously shown that infection with HP induces the formation of invadosomes in hepatocytes. We are currently investigating the mechanism behind this phenomenon using in vitro approach complemented with transcriptome sequencing.<\/li>\n<li>Clinical aspects of Helicobacter pylori-induced liver diseases. We are using the livers of mice infected with HP to analyse short- and long-term effects of the infection with focus on different markers such as YAP1 and CD44.<\/li>\n<li>Alteration of gut microbiota by Helicobacter pylori leading to the progression of liver diseases. For this study, we are collecting samples from Estonian patients. Our goal is to characterize Estonian HP strains, their effect on mouth\/stomach\/gut microbiota and liver.<\/li>\n<li>Effect of probiotic lactic acid bacteria on HP and HP-induced inflammatory response.<\/li>\n<\/ul>\n<p style=\"display: none;\">actin cytoskeleton, Helicobacter pylori, invadosomes, liver damage, microbiome<\/p>\n","protected":false},"template":"","tags":[1487,1519,1591,1650,1691],"research_cat":[2057],"class_list":["post-5469","research","type-research","status-publish","hentry","tag-helicobacter-pylori-en","tag-actin-cytoskeleton","tag-invadosomes","tag-liver-damage","tag-microbiome","research_cat-faculty-of-science"],"acf":{"research_manager":4909,"related_team":[4969,4664,4241,4377]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Biomedicine - Health and Food Technologies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/healthandfood.taltech.ee\/en\/researches\/biomedicine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biomedicine - Health and Food Technologies\" \/>\n<meta property=\"og:description\" content=\"Biomedicine lab investigates human pathogen Helicobacter pylori (HP) and its role in the development of liver diseases. HP is a Gram-negative bacterium living in the hostile environment of the human stomach. About 70% of the adult population in Estonia is infected with HP. The bacterium causes gastritis and peptic ulcers, and, in some cases, gastric [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/healthandfood.taltech.ee\/en\/researches\/biomedicine\/\" \/>\n<meta property=\"og:site_name\" content=\"Health and Food Technologies\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-29T15:05:54+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/researches\\\/biomedicine\\\/\",\"url\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/researches\\\/biomedicine\\\/\",\"name\":\"Biomedicine - Health and Food Technologies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/#website\"},\"datePublished\":\"2024-11-13T05:32:56+00:00\",\"dateModified\":\"2025-04-29T15:05:54+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/researches\\\/biomedicine\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/researches\\\/biomedicine\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/researches\\\/biomedicine\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Biomedicine\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/\",\"name\":\"Tervise- ja toidutehnoloogiate fookustippkeskus\",\"description\":\"Health and food technology activities\",\"publisher\":{\"@id\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/#organization\",\"name\":\"TalTech\",\"url\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/wp-content\\\/uploads\\\/2024\\\/12\\\/cropped-taltech-favorites.webp\",\"contentUrl\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/wp-content\\\/uploads\\\/2024\\\/12\\\/cropped-taltech-favorites.webp\",\"width\":512,\"height\":512,\"caption\":\"TalTech\"},\"image\":{\"@id\":\"https:\\\/\\\/healthandfood.taltech.ee\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Biomedicine - Health and Food Technologies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/healthandfood.taltech.ee\/en\/researches\/biomedicine\/","og_locale":"en_US","og_type":"article","og_title":"Biomedicine - Health and Food Technologies","og_description":"Biomedicine lab investigates human pathogen Helicobacter pylori (HP) and its role in the development of liver diseases. HP is a Gram-negative bacterium living in the hostile environment of the human stomach. About 70% of the adult population in Estonia is infected with HP. 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