Aivar Lõokene

Researches

  1. Biochemistry of lipids and lipoproteins

Publications

Nucleolin perturbation alters membrane lipid homeostasis
Journal / Periodical: Molecular Omics
Authors: Zahavi, Eitan Erez; Rishal, Ida; Oses-Prieto, Juan A.; Brandis, Alexander; Malitsky, Sergey; Itkin, Maxim; Pokorna, Sarka; Cabrera-Cabrera, Florencia; Seeba, Natjan-Naatan; Risti, Robert; Lookene, Aivar; Futerman, Anthony H.; Burlingame, Alma L.; Fainzilber, Mike; Koppel, Indrek
Year: 2025
Leptin acutely increases hepatic triglyceride secretion in patients with lipodystrophy
Journal / Periodical: Metabolism
Authors: Beghini, Marianna; Metz, Matthäus; Baumgartner, Clemens; Wolf, Peter; Bastian, Magdalena; Hackl, Martina; Baumgartner-Parzer, Sabina; Marculescu, Rodrig; Krebs, Michael; Harreiter, Jürgen; Brandt, Stephanie; Miehle, Konstanze; Ceccarini, Giovanni; Magno, Silvia; Pelosini, Caterina; Tran, Christel; Gambineri, Alessandra; Cecchetti, Carolina; Gard, Liliana-Imi; Risti, Robert; Lõokene, Aivar; Krššák, Martin; Pfleger, Lorenz; Trauner, Michael; Kautzky-Willer, Alexandra; Stumvoll, Michael; Wabitsch, Martin; Santini, Ferruccio; Turan, Ihsan; Akinci, Baris; Frommlet, Florian; Stangl, Herbert; Fürnsinn, Clemens; Scherer, Thomas
Year: 2025
A negatively charged cluster in the disordered acidic domain of GPIHBP1 provides selectivity in the interaction with lipoprotein lipase.
Journal / Periodical: Scientific Reports
Authors: Risti, Robert; Reimund, Mart; Seeba, Natjan-Naatan; Lõokene, Aivar
Year: 2024

Projects

Investigation of hypertriglyceridemia drug candidates
Year: 2024 - 2025
Using surface plasmon resonance and calorimetry, the binding of hypertriglyceridemia drug candidates to lipoprotein lipase was tested.
Development of a human lipoprotein lipase drug for the treatment of hypertriglyceridemia
Year: 2023 - 2023