Mari-Liis Leinus

The rapid emergence of new illegal drugs (HHC, nitazenes, synthetic cathinones, etc.) creates a need for fast, on-site drug testing tools that can detect multiple substances in biofluids. These tools are crucial for clinicians, anti-doping experts, and law enforcement. Multiplexed portable analytical tools have a great potential to be implemented for this purposes. Moreover, such kind of instruments could be utilized in personal healthcare monitoring by enabling early-stage diagnostics of health problems. This project aims to develop electrophoresis-based analytical tools for reliable, fast and cost-effective metabolism studies in vitro, revealing the characteristics and metabolic pathways of new psychoactive substances. Additionally, new on-site biofluid testing tools (focused on oral fluid) will be developed for detecting new drugs. The results of this project will enhance drug monitoring, support public health, and improve safety.

The research infrastructure on experimental studies and applications of cellular processes aims at gathering national know-how in the field of cell and molecular biology, and aims at setting up an instrumental capability to develop competence and services in the fields of microbial and mammalian cell processes and their applications. The infrastructure will be built up jointly by the University of Tartu, Tallinn University of Technology, Tallinn University, Estonian University of Life Sciences and the Institute of Chemical Physics and Biophysics. The vision is to become a know-how and service centre to partner health, biotechnology and environment-focused public sector organisations, medical institutions, biotechnology and pharmacological companies. The focus will be on acquiring and setting up relevant instrumental complexes, development and offering of services, popularisation and dissemination of the field in order to ensure sustainability of researchers and future activities.

Ukraine has a quarter of the world’s chernozems and 41.5 million hectares of agricultural land, covering 70 percent of the country. Agriculture pollutes about 60 percent of land resources and approximately 45-48 percent of reservoirs, representing 18-24 % of global GHG emissions. SmartAGRO's goal is to develop a precision fertilization solution that will help Ukraine achieve its climate policy goals. SmartAGRO is based on capillary electrophoresis technology, which enables the determination of various macro- and microelements in the soil. The goal is to develop a precise agriculture platform with recommendations for soil fertilization for agricultural crops growing in Ukraine, taking into account the chemical profile of the soil, the type and the crops grown, helping to reduce the use of fertilizers, increase/maintain yields and reduce GHG emissions.