Projects

The central research focus of the technology and economics of trust in software theme will be certified software. Topics of research include: • methods and tools for certification of software; program analysis, transformation, generation; in particular for big data, cloud and IoT; • static analysis (model checkers, theorem provers), verification, systematic testing; • contract languages, languages with powerful type systems (refinement types, dependent types); domain-specific languages; • program synthesis and program learning, program understanding; • repositories of certified software, evolution of certified software; • trust in closed-source software, gradual trust-building; • trading trust, pricing of trust, game theory of trust.

The aim of the project is to develop new types of energy materials: (1) MNC type electrode catalysts for carbon dioxide reduction; (2) new calcium-based electrolytes for calcium and related batteries; (3) testing of these materials in equipment devices; (4) Optimized devices (specifically, multi-layer filters) for large-scale reversible applications in metal recuperation, incl. selective adsorbents, electrochemical methods and absorbers for the separation of rare-earth metals and for the treatment of the residual water.

The aim of this study is to determine the physico-chemical parameters and the content of selected bioactive substances of bee bread samples collected from different counties of Estonia.

The project “An innovative platform for Estonia-Norway research-based teaching in bioinformatics and gene editing” will develop tools for teaching two cutting-edge technologies needed in almost all fields of Life Sciences. The project will be coordinated by TalTech and will have as partner NMBU. Group leaders are plant scientist experts in one of these technologies with teaching experience at universities. During the project, material for lectures and practical work in the laboratories will be developed. These tools will be tested in two 10 days long intensive courses for MSc and PhD students. During the courses, students will benefit from interaction with another culture in a different educational atmosphere. The tools developed will be presented at the end of the project in a seminar in TalTech with PhD students presenting their work. A special emphasis will be given to gene editing technologies, including science policy, since this topic is of interest to different stakeholders.

Wood is the most abundant form of biomass used by industry and is the source of the three major biolpolymers in nature – cellulose, hemicellulose and lignin. While cellulose is responsible for about 40-50% of the dry weight of wood, lignin content varies from 10% to about 35% across species. For decades, lignin has been seen as a bothersome side-product that needs removal at all cost. However, in the last decade, due to its polyphenolic nature, lignin has emerged to the focus of attention as a renewable alternative to crude oil based chemistry. The project aims to develop technologies for the extaction and fractionation of lignin and cellulose derived from low valorization level bleached chemi-thermomechanical pulp or industrial wood-waste. The goal of the project is to develop practical and environmentally friendly functional materials (e.g. thermo isolators and surfactants). Also, the project will identify and characterize novel industrial enzymes from extreme thermophilic organisms.

Development of adaptable supramolecular chirality sensors is important for the industry and academia. Chiral molecules, in nform of enantiomers, are commonly used in the pharmaceutical, food, perfume, cosmetic, and agricultural industries. In biological ecosystems, chiral molecules are metabolized, absorbed, and excreted selectively, and their biological effects can vary significantly. Therefore, the environmental impact of different stereoisomers can be radically different. Standard analysis methods that do not distinguish the chirality of molecules may underestimate the effects of these compounds. In this project, we designed and synthesized new receptor molecules through both supramolecular interactions and covalent bonding. By investigating the structure, optical, and supramolecular properties of the obtained receptor molecules, we reached several new compounds with the potential to be applied for separation, isolation, and detection of bioactive compounds and environmental pollutants. We developed environmentally friendly mechanosynthesis methods to reduce waste production during the synthesis process of organic compounds. Additionally, we studied formation of oligomeric macrocyclic receptors and developed methods for obtaining both mono- and multifunctional macrocyclic compounds. We initiated research on the creation of supramolecular materials and demonstrated that materials for enantioselective electronic noses can be easily prepared using porphyrins and chiral hemicucurbiturils. We also investigated the correlation between the circulardichroism signal generation and molecular orbitals and geometries modelled by quantum chemical methods. We also showed that the signal of the studied optically active sensor molecules can be amplified via interaction with inorganic chiral materials. The results of the project were published in number of research articles and two patents were applied for.

Prolonging the shelf life of food is important to reduce food losses in supply chain and consumption as well as enable products to be marketed longer distance. Measures to extend the shelf life are directly related to food safety and quality; however, its sensory properties are best within a certain optimal shelf life. Although human sensory receptors are set by nature to identify food safety risks, good taste does not necessarily guarantee food safety and vice versa. Safety risks are particularly high for unpasteurised products with neutral pH. The temperature of 2-6°C used in the supply chain does not prevent the growth of spoilage, including pathogenic, bacteria and thus limits the shelf life. This project explores various technical options for extending the shelf life of food without sacrificing safety and quality: incl. aseptic production, rapid cooling, use of ice binding proteins and storage temperatures of -2...0°C as well as control of essential flavor components.

The basic structure and dynamics of Estonian energy and transport systems can be traced back to Western industrial states in the interwar era. Currently both systems produce large negative environmental impacts: furthermore, unequal distribution of these impacts intensifies social inequality. Estonia's success in the field of information technology might help to alleviate these tendencies. However, studies show that careless application of ICT-s might lead to worsening environmental and social conditions. The project focuses on three Estonian systems – energy, transport, communications – aiming to analyse their history and to design interventions for shaping their development onto sustainable and just path without repeating the past mistakes of industrial societies in developing, applying and regulating technologies. It is based on a novel Deep Transitions framework, conceptualizing the evolution of industrial society through the interactions of socio-technical systems.

The most significant findings are related to development of the novel wireless closed-loop patient support system i) energy-efficient protocols for body area networks and ii) fast computing methods for the real-time gait analysis. These novel contributions are relevant for the electrical stimulation of the muscles of the patients suffering from neurological diseases (e.g., multiple sclerosis), in particular assisting them with daily life activities. The outcomes of the project are significantly relevant to society because they directly enhance the state-of-the-art assistive devices. The project has created a wider impact in the following ways: 1- ETSI SmartBAN Standard: “Applying SmartBAN MAC (ETSI TS 103 325) for various use-cases”, Work Item Reference, DTR/SmartBAN-0014, Rapporteur, Muhammad Mahtab Alam, -- ETSI SmartBAN is a specific standard for the low-power body area networks and this project usecase is introduced in this workitem which motivated the needs for the future standard compliant devices. 2- Invention: System and method for self-assessment of physical capabilities and condition changes; Owners: Tallinn University of Technology, Motionmon OÜ; Authors: Alar Kuusik, Katrin Gross-Paju, Muhammad Mahtab Alam; Priority number: US16/268134; Priority date: 5.02.2019. 3- Collaboration with Hospitals: We had a positive collaboration with i) East Tallinn Central hospital and ii) West Tallinn Central hospital with specific neurological departments. The methods developed in this project and future devices (beyond this project) comply with the needs of the patients and this will enable enhanced comfortable and effective non-invasive electrical stimulation devices to be used by the patients. Overall, the project yielded significant research output in terms of numbers of scientific publications including 9 Journal and 13 conferences of high quality and impact. So far, these papers are strongly cited by the relevant research community (h-index=9, h-10=9).