Projects

The project deals with the development of sustainable methods of asymmetric catalysis and their application in the synthesis of biologically relevant compounds. Various methods of catalysis (organo-, metal- and enzymatic catalysis) will be used separately or in cooperative manner. Special attention will be turned to the increase of efficiency of reactions by using selective catalysts, cascade or one-pot reactions. As a new method, a halogen bond donor catalyzed asymmetric reactions will be studied. New reactions will be applied on the synthesis of biologically active compounds and their derivatives. As a result, new asymmetric catalytic sustainable methods for the creating molecular complexity will be developed. Principles of green chemistry will take root in science, in the mode of thinking of PhD students and by PhD graduates in Estonian chemistry enterprises.

The transition towards a clean economy requires novel processes for chemical, material, and liquid fuel production that use sustainable substrates, have improved life cycle, and hence a reduced carbon footprint. Cell factories provide the ultimate platform for this purpose to drive the world economy and mitigate risks emanating from climate change. An exponential increase in process productivity by rapid technological developments in the fields of additive manufacturing and synthetic biology has the potential to influence nearly every industry because of adaptability and continual cost reduction. In this project, we offer interdisciplinary research that combines the advances in additive manufacturing of living materials with synthetic biology of non-conventional yeasts to manufacture a novel flow chemistry platform for creating biorefineries that can convert sustainable, locally available substrates into value-added oleochemicals with an aim to meet sustainability goals of society.

In heart muscle cells, energy is transferred from mitochondria to multiple locations in the cell, where it is utilized to perform mechanical work and maintain ion balance. On the molecular diffusion pathway, several intracellular structures impose restrictions, which are prominent in healthy cells and, some data suggests, disappear in disease. While the restrictions and some clinical data point towards a major role of creatine kinase (CK) assisted energy transfer in the cell, data from loss-of-function animal models are equivocal. In this project, we will develop and use state-of-the-art experimental and mathematical modeling approaches to characterize the diffusion environment within cardiomyocytes and quantify the role of CK in the healthy heart. By identifying the adaptations in transgenic mice, we expect to identify new treatment targets for heart failure patients with reduced CK flux.

The general objective of this project is to create an "umbrella architecture" based on existing EBSI services. The architecture builds the basis for the realization of traceability application scenarios. Furthermore, TRACE4EU focuses on engagement with pan-European stakeholders and promotion of recommendations for further development of the EBSI eco-system.

Astrocytes comprise one of the main cell types in the central nervous system (CNS), and it is now recognized that they have important roles in ensuring proper development and homeostasis of the CNS, with astrocyte dysfunction contributing to all major neurological disorders. Recent studies have shown that these cells undergo dramatic transcriptional changes in response to neuron-derived stimuli. However, what are the astrocyte-specific mechanisms that regulate these changes are still largely unknown. Here, this issue will be tackled using state-of-the art functional genomic approaches to generate a comprehensive map of the astrocyte-specific regulatory elements (with a focus on enhancers) and transcription factors that govern stimuli-induced gene expression changes. This will provide unique and original insights into the mechanisms that control stimuli-induced gene expression in non-neuronal CNS cells, with potential implications for the understanding of several neuropathologies.

Public administrations across Europe face double pressure to adjust to the digital age while inducing sustainable development. As they do so, the governments need to develop new, and redevelop old, public administration and policy capabilities. The current project rests on the assumption that public administrations form a pivotal yet often neglected cog in social shaping of technological progress driving the sustainable future. The objective of the PAFSD project is to create a new generation world-class research, teaching and knowledge transfer capabilities at the cross-roads of public administration, digital transformation and sustainable transition at TalTech, Estonia. This will be achieved by complementing the existing unique knowledge base of TalTech with training a new generation early-career researchers, exchanging new knowledge between senior researchers and support staff, developing new educational capabilities, actively engaging in policy networks internationally, enhancing organizational capabilities and doing a hands-on small-scale research project. The PADST project will pool the competences of three of the leading European research universities - KU Leuven, Universiteit Utrecht, and University College London - with TalTech to develop an international cutting-edge research center studying and shaping public administration capabilities fit for the digital and sustainable future in Estonia, Europe and beyond.

Copper is an essential cofactor for more than twenty enzymes crucial for cellular energy production, antioxidative defense, and oxidative metabolism. Free copper ions, however, are toxic and copper metabolism is therefore highly controlled. Dysregulation of copper homeostasis occurs in multiple diseases, including Wilson's (WD) and Alzheimer's disease (AD). This project strives to develop a comprehensive understanding of human copper metabolism and tools for its regulation. This will be achieved using a systems biology approach, which we applied earlier to intracellular Cu(I) proteome. We will expand this research to Cu(II) proteome in the blood and cerebrospinal fluid by using a novel LC-ICP MS-based approach. The expected results will substantially advance the knowledge on copper metabolism, and facilitate the search for molecular tools for its regulation. The latter will be tested in cellular and animal disease models and could provide novel molecular tools for WD and AD treatment.

Bone loading is the stress on bones during physical activity. It affects bone health and current wearable devices cannot measure it accurately. OsteoSense uses minature biosensors to capture human motion and machine learning to estimate bone loading, providing feedback and expert guidance directly on your smart phone. The system will be tested by leading experts in Estonia and professional football and racing teams in the UK, providing a world-class solution for indoor and outdoor human motion capture and bone loading reporting.

Particle accelerators are a key asset of the European Research Area. Their use spans from the large installations devoted to fundamental science to a wealth of facilities providing X-ray or neutron beams to a wide range of scientific disciplines. Beyond scientific laboratories, their use in medicine and industry is rapidly growing. Notwithstanding their high level of maturity, particle accelerators are now facing critical challenges related to the size and performance of the facilities envisaged for the next step of particle physics research, to the increasing demands to accelerators for applied science, and to the specific needs of societal applications. In this crucial moment for accelerator evolution, I.FAST aims at enhancing innovation in and from accelerator-based Research Infrastructures (RI) by developing innovative breakthrough technologies common to multiple accelerator platforms, and by defining strategic roadmaps for future developments. I.FAST will focus the technological R&D on long-term sustainability of accelerator-based research, with the goal of developing more performant and affordable technologies, and of reducing power consumption and impact of accelerator facilities, thus paving the way to a sustainable next-generation of accelerators. By involving industry as a co-innovation partner via the 17 industrial companies in the Consortium, 12 of which SME’s, I.FASTwill generate and maintain an innovation ecosystem around the accelerator-based RIs that will sustain the long-term evolution of accelerator technologies in Europe. To achieve its goals, I.FAST will explore new alternative accelerator concepts and promote advanced prototyping of key technologies. These include, among others, techniques to increase brightness and reduce dimensions of synchrotron light sources, advanced superconducting technologies to produce higher fields with lower consumption, and strategies and technologies to improve energy efficiency.

"The objective of the project is to answer the needs of the bioeconomy sector in well-trained graduates, able to develop innovative and sustainable bio-based products and bioprocesses, and ensure their integration into alternative value chains and different bioeconomy sectors. Bioceb consists of a dedicated 2years (4-semester) MSc joint programme, with a core in-depth training in biotechnology encompassing biological resource diversity and optimal use, bioprocess design and upscaling, and biobased products engineering for targeted markets, with complementary focus on soft skills including project management. In order to promote the development of sustainable and circular bioeconomy systems, the programme goes beyond the biomass processing technical issues, by providing knowledge of green chemistry principles, tools for socio-economic and environmental assessment, experience of facing real-life bioeconomy challenges through projects and examples of flexible biorefinery systems adapted to local contexts. Five academic institutions, the Partners, collaborate intensively to offer joint study modules in addition to their existing curricula. Moreover, a group of strategic associated partners is settled with members from Eu- and Non-EU Universities, research Institutions and socio-economic partners, to contribute to the curricula in internship and masterthesis writing and achievement of learning outcomes. "